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Hit Optimization
Strategies to optimize initial crystallization hits: |
![]() Chemical EnvironmentKits and screens to optimize the chemical composition of your crystallization reagents, i.e. buffer pH, precipitant and additive compostion. |
![]() Input ProteinGet your protein ready for crystallization! Consider to optimize the solubilization buffer, alter the protein surface or modify the sequence by truncation or mutagenesis. Or try a new mode of production. |
![]() Thermodynamics / KineticsDo not discard bad diffracting crystals! They can be very useful, too. Try to improve diffraction by varying the solvent content or use your initial crystals for seeding. |
| Chemical Environment | Input Protein | Thermodynamics-Kinetics |







